Wei Chen

Unified cell segmentation for spatial transcriptomics via transcript reassignment

Tracel improves cell segmentation in spatial transcriptomics by assigning transcripts to cells using optimal transport, enhancing cell-type separation and reducing contamination.

A synchronization modulation electric field reduces early ischemic kidney injury in pigs and suppresses a stress and inflammatory program without detectable leukocyte accumulation

Modified 3rd Generation Synchronization Modulation Electric Field (3m-SMEF) Prevents Ischemia-Reperfusion-Induced Acute Kidney Injury via Targeting Na⁺/K⁺-ATPase

The paper demonstrates that modified 3rd-generation SMEF (3m-SMEF) protects against ischemia-reperfusion-induced AKI by preserving Na/K-ATPase function and tubular integrity in vitro and in vivo.

Design of synthetic activators for programmable gene expression

This study designs synthetic activators for programmable gene expression by engineering coactivator-binding proteins and demonstrates their enhanced transcriptional activation capabilities.

An integrated landscape of mRNA and protein isoforms

The paper integrates mRNA and protein isoform data in human RPE-1 cells to reveal widespread translation of alternative transcripts and proteolytic processing as a major source of proteome complexity.

Fibulin-2 transduces a matrix-to-metabolism signal in kidney fibrosis

This study identifies Fibulin-2 as a matrix cue that transduces fibrotic ECM remodeling into mitochondrial metabolic reprogramming in kidney fibrosis.

Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

This study investigates how the order of early mutations affects tumor initiation in colorectal cancer using engineered murine organoids, finding that mutation order influences tumorigenic properties and immune interactions.

Cervical Repetitive Magnetic Stimulation Enhances Respiratory Recovery by Modulating Neuronal Plasticity After Cervical Spinal Cord Injury

Cervical repetitive magnetic stimulation improves ventilatory recovery after spinal cord injury by enhancing diaphragm activity and reducing inflammation.

The ZmHEAT1/ZmKAKU42-ZmNCH1 module regulates heat stress tolerance by modulating nuclear envelope structure in maize

The paper identifies a gene module that modulates nuclear envelope structure to enhance heat stress tolerance in maize.

Respiratory viral infections prime accelerated lung cancer growth

This study shows that prior respiratory viral infections like SARS-CoV-2 or influenza accelerate lung tumor growth by altering the immune environment and promoting a pro-tumor microenvironment.

In situ generated vaccine-like pyroptosome for personalized cancer immunotherapy

This paper develops a nanoadjuvant that induces localized pyroptosis to generate vaccine-like pyroptosomes, enhancing anti-tumor immunity while avoiding systemic toxicity.

Z-RNA-ZBP1 axis drives Tau-mediated neurodegeneration

The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.

Unveiling Distinct Neuroimmune Responses in Mouse Models of Cervical Spinal Cord Injury: Hemisection versus Hemicontusion

This study compares neuroimmune responses in two cervical spinal cord injury models in mice, finding distinct inflammatory and repair profiles between hemisection and hemi-contusion injuries.

Glycosphingolipids Regulate Phosphatidylserine Transport at ER-PM Contact Sites

This study shows glycosphingolipids regulate phosphatidylserine transport at ER-PM contact sites by maintaining ORP5 and ORP8 localization and function.

Design of Orthogonal Far-Red, Orange and Green Fluorophore-binding Proteins for Multiplex Imaging

The paper designs orthogonal fluorophore-binding proteins using deep learning for multiplex imaging, demonstrating high specificity and utility in labeling and monitoring subcellular processes.

Resorbable Poly-(D,L)-Lactide Anchorage of Nanoparticulate Mineralized Collagen Materials Maximizes In Vivo Skull Regeneration

This study evaluates MC-GAG scaffolds with PDLLA fixation for cranial defect regeneration, finding enhanced bone mineralization and mechanical properties compared to controls.

Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging

This study develops a pipeline to generate brain connectomes using photoacoustic ultrasound in mice, showing comparable results to fMRI in detecting known connections.

Analyzing the Molecular Mechanism of Eucalyptol, Limonene and Pinene Enteric Capsules (QIENUO) in the Treatment of Pulmonary cystic fibrosis with Network Pharmacology and Verifying Molecular Docking

This study investigates the molecular mechanism of QIENUO in treating pulmonary cystic fibrosis using network pharmacology and molecular docking, identifying key pathways and active compounds.

HDAC6 regulates radiosensitivity of non-small cell lung cancer by promoting degradation of Chk1

This study shows HDAC6 promotes degradation of Chk1, and its inhibition increases radiosensitivity in NSCLC by preventing Chk1 resolution after radiation.

Identification of key genes related to dexamethasone-resistance in acute lymphoblastic leukemia

The paper identifies 20 key genes associated with dexamethasone resistance in acute lymphoblastic leukemia using differential expression and protein-protein interaction analysis.

A QM/MM Study of Biomimetic Catalysis of Diels-Adler reactions Using Cyclodextrins

This study uses computational methods to investigate how cyclodextrins catalyze Diels-Alder reactions by pre-organizing reactants and reducing activation energy.

Genome of octoploid plant maca (Lepidium meyenii) illuminates genomic basis for high altitude adaptation in the central Andes

This study reports the genome of octoploid maca, revealing how whole genome duplications contribute to high altitude adaptation in the Andes.

Genome sequencing of the perciform fish Larimichthys crocea provides insights into stress adaptation

This study sequenced the genome of the large yellow croaker to understand its adaptation to environmental stress, finding expanded gene families and novel regulatory networks involved in stress response.