Author

Jonathan Bradshaw

Imperial College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Gad M. FrankeliD· 4 shared Joshua L. C. WongiD· 4 shared Julia Sanchez‐GarridoiD· 3 shared Immaculada Margarit Y Ros· 2 shared Jaie Rattle· 2 shared Maria Rosaria Romano· 2 shared Mariagrazia PizzaiD· 2 shared Sophia DavidiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersMicrobiology

Gad M. FrankelORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

PgaR is a positive regulator of the pgaABCD biosynthetic operon in Klebsiella pneumoniae

Jonathan Bradshaw, Julia Sanchez‐Garrido, Sophia David, Mariagrazia Pizza, Immaculada Margarit Y Ros, Maria Rosaria Romano, Joshua L. C. Wong, Gad M. Frankel

This paper identifies PgaR as a positive regulator of the pgaABCD operon in Klebsiella pneumoniae, showing that genetic variation in this region leads to loss or hyper-production of PNAG, with distinct fitness consequences.

Infection and Immunity · Sep 24, 2026Peer-reviewedMicrobiology

citrOgen: a synthesis-free polysaccharide and protein antigen-presentation to antibody-induction platform

Joshua L. C. Wong, Julia Sanchez‐Garrido, Jaie Rattle, Jonathan Bradshaw, Vishwas Mishra, Gad M. Frankel

The paper introduces a platform using Citrobacter rodentium to generate antibodies against bacterial polysaccharides and proteins without requiring purified or synthetic antigens.

Nature Communications · Oct 6, 2025Peer-reviewedMicrobiology

Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT

Chloe Seddon, Sophia David, Joshua L. C. Wong, Naito Ishimoto, Shan He, Jonathan Bradshaw, Wen Wen Low, Gad M. Frankel, Konstantinos Beis

The paper determines the cryo-EM structure of TraT proteins from plasmids and reveals their evolutionary history, showing independent acquisition by different plasmid backbones.

Nature Communications · Jan 14, 2025Peer-reviewedMicrobiology

The exopolysaccharide Poly-N-Acetyl-Glucosamine (PNAG) coats Klebsiella pneumoniae in vivo

Jonathan Bradshaw, Julia Sanchez‐Garrido, Rita Berkachy, Jaie Rattle, Connor Preston, Mariagrazia Pizza, Immaculada Margarit Y Ros, Maria Rosaria Romano, Joshua L. C. Wong, Gad M. Frankel

This paper shows that Klebsiella pneumoniae produces extracellular PNAG in vitro but switches to cell-associated PNAG during lung infection, highlighting its potential as a vaccine antigen.

bioRxiv · Sep 23, 2024 · PreprintMicrobiology