A secreted fatty acid- and retinol- binding protein from Heligmosomoides polygyrus suppresses host macrophage polarization
Pakeeza Azizpor, Janice Montoya, Fayez Eyabi, Jose Ramirez, Tara Hill, Robert Pena, Manisha Mishra, Martin J. Boulanger, Adler R. Dillman
This study identifies Hp-FAR-2, a secreted fatty acid- and retinol-binding protein from H. polygyrus, which suppresses macrophage polarization by modulating both M1 and M2 markers, potentially aiding parasite persistence.
bioRxiv · Jun 5, 2025 · PreprintBiochemistry