A bistable type III secretion system is primed and loaded in Pseudomonas aeruginosa hypervirulent isolates with positively selected codon changes in exsA or exsD
Arianna D. Reuven, Sarah Katzenell, Alexander Rapp, Julian Oates, Joseph Pennington, Thomas H. Hampton, Jennifer M. Bomberger, Joshua L. Cherry, James B. Bliska
The paper identifies positively selected codon changes in exsA or exsD that hyperactivate the T3SS in P. aeruginosa, leading to hypervirulence through increased T3SS activity and immunopathology.
bioRxiv · Oct 26, 2026 · PreprintMicrobiology