Arianna D. Reuven

This study shows that Pseudomonas aeruginosa CF isolate DH1137 reduces inflammasome activation and IL-1β release in alveolar macrophages under hypoxia, potentially aiding immune evasion in cystic fibrosis.

The paper identifies positively selected codon changes in exsA or exsD that hyperactivate the T3SS in P. aeruginosa, leading to hypervirulence through increased T3SS activity and immunopathology.

The paper shows that a hyperactive T3SS mutant of P. aeruginosa enhances neutrophil plasma membrane rupture via ExoS ADPRT activity, which is inhibited by glycine.

This study shows that Burkholderia cenocepacia and orbicola trigger distinct macrophage death pathways, with cenocepacia using the caspase-11 inflammasome and orbicola using a TecA-dependent alternative pathway.

This study investigates how 5-azacytidine induces DNA damage, homologous recombination, and genetic mutations in E. coli, revealing Dcm-dependent and -independent mechanisms of mutagenesis and DNA repair.