Joshua B Plotkin

Host-pathogen coevolution and the emergence of broadly neutralizing antibodies in chronic infections

This study develops a mathematical framework to analyze coevolutionary dynamics between antibodies and viruses in chronic infections, identifying parameters and signatures that predict the emergence of broadly neutralizing antibodies.

Assortative mating can impede or facilitate fixation of underdominant alleles

The paper shows that assortative mating can either hinder or promote the fixation of underdominant alleles, depending on mating opportunities and selection pressures.

Epistasis and the dynamics of reversion in molecular evolution

The paper analyzes how reversion rates of amino acid substitutions decrease over time in the presence of epistasis, showing that longer absence leads to lower reversion probability.

The evolutionary advantage of heritable phenotypic heterogeneity

This study investigates how phenotypic plasticity confers evolutionary advantages by analyzing fixation probabilities of plastic alleles under different environmental conditions and heritability levels.

Improved ribosome-footprint and mRNA measurements provide insights into dynamics and regulation of yeast translation

The paper improves ribosome-footprint and mRNA measurements in yeast, revealing new insights into translation dynamics and regulation.