Origin-1: a generative AI platform for de novo antibody design against novel epitopes
Simon Levine, Jonathan Edward King, Jacob Stern, David Grayson, Raymond Wang, Rui Yin, Umberto Lupo, Paulina Kulytė, Ryan M. Brand, Tristan Bertin, Robert Pfingsten, Jovan Cejovic, Chelsea Chung, Breanna K. Luton, Andrew Hagemann, , Amir Shanehsazzadeh
Origin-1 generates high-confidence, specific antibodies against zero-prior epitopes through generative AI, validated with biophysical assays and cryo-EM.
bioRxiv · May 5, 2026 · PreprintMolecular Biology