Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Simon Levine, Jonathan Edward King, Jacob Stern…·Amir Shanehsazzadeh
Origin-1 generates high-confidence, specific antibodies against zero-prior epitopes through generative AI, validated with biophysical assays and cryo-EM.
Amir Shanehsazzadeh, Julian Alverio, George W. Kasun…·Sharrol T. Bachas
IgDesign designs antibody CDRs using deep learning and validates them in vitro, showing high success rates and improved affinities for multiple therapeutic antigens.
Amir Shanehsazzadeh, Matt McPartlon, George W. Kasun…·Sharrol T. Bachas
Deep generative models combined with high-throughput screening design de novo anti-HER2 antibodies without further optimization, yielding nanomolar binders functionally comparable or superior to trastuzumab.