Staphylococcus aureus triggers isolate-specific host transcriptional responses alongside TNF-R1 regulated cell death
Annika Walter, Thorsten Bischler, Marvin Jungblut, Leonhard F. Breitsprecher, Johanna Beck, Lucia Hofmann, Nicole Schäfer, Tanja Ziesmann, Silke Haerteis, Iana Gadjalova, Ute Distler, Gerti Beliu, Katherina Psathaki, Michael Hensel, Wulf Schneider‐Brachert, , Juergen Fritsch
This study shows that different S. aureus isolates trigger unique host transcriptional responses and cell death pathways, with TNF-R1 playing a key role in regulating infection outcomes in U937 cells.
bioRxiv · May 7, 2026 · PreprintMicrobiology