Ute Distler

The paper introduces MAPPIE, a method to map human protein-protein interactions into a 2D space for functional discovery, outperforming baselines in sparse interaction regions.

This study investigates the role of PHB2 in T cell proliferation, differentiation, and effector functions, finding that PHB2 deficiency causes cell cycle arrest and metabolic dysfunction.

This study identifies p1/s1, a 3'-nucleotidase/nuclease in Leishmania major, which helps the parasite evade host immune responses by generating adenosine and degrading neutrophil extracellular traps.

This study shows that different S. aureus isolates trigger unique host transcriptional responses and cell death pathways, with TNF-R1 playing a key role in regulating infection outcomes in U937 cells.

This study identifies PfATG18 as a regulator of vacuolar membrane dynamics in malaria parasites, linking V-ATPase assembly to endocytic processes and drug resistance.

This study shows that the Plasmodium heme detoxification protein (HDP) is essential for mitochondrial protein biosynthesis, not hemozoin formation, and its loss disrupts mitochondrial function and parasite survival.

The paper compares CCR8+ Treg cells in tumor and tumor-free tissues using chromatin accessibility and DNA methylation, finding high similarity suggesting tumor microenvironment activation of tissue Treg cells.

This study identifies IRF4 interactors and their role in regulating context-dependent transcriptional programs in Th17 and Treg cells using ChIP-Seq and proteomics.

MAETi enables immunopeptidome profiling from 1E4 cells with high peptide coverage and SAV epitope detection.

This study identifies PfSET10 as a H3K18 methyltransferase in Plasmodium falciparum that regulates chromatin structure and is essential for intraerythrocytic development.

This paper identifies SV2A as a mitochondrial outer membrane protein that regulates mitochondrial morphology and autophagy through interactions with DRP1 and ATG9A.

The paper benchmarks dia-PASEF with timsTOF HT for high-throughput proteome analysis in a multi-center study, showing consistent protein and peptide identification across laboratories.

The paper identifies novel proteins in Plasmodium falciparum gametocyte egress vesicles using imaging and BioID, revealing distinct proteomes for osmiophilic bodies and g-exonemes.

The paper introduces midiaPASEF, a DIA scan mode that enhances information content in proteomics, enabling precise precursor m/z determination and efficient automated processing.