Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T cell receptor signalling.
Edward John Lloyd Armstrong, Matthew Kin-Liang Chiu, Shane Foo, Lizzie Appleton, Pablo Nenclares, Anton Patrikeev, Nitya Mohan, Martin Mclaughlin, Galabina Bozhanova, Julia Hoebart, Victoria Roulstone, Emmanuel Christian Patin, Malin Pedersen, Joan Kyula, Masahiro Ono, , Victoria A. Jennings
This study shows that combining oncolytic Maraba virus with PD-1 blockade overcomes resistance in advanced melanoma with a cold tumor microenvironment.
Journal for ImmunoTherapy of Cancer · Jul 1, 2024Peer-reviewedCancer Biology