Mesaconic acid delivery via biomaterials and engineered probiotics to the gut reduces inflammation in Crohn's Diseases mouse models
Huikang Qian, Drishtant Singh, Zixuan Chen, Wenfei Zhao, Bo Zhang, Taravat Knodaei, Abhirami Thumsi, Sanmoy Pathak, Abhirami Suresh, Paola Menghini, Julia Schiek, Viveka Rabara, Carlo De Salvo, Harihara Baskaran, Yuji Aso, , Abhinav P. Acharya
The paper develops two strategies to increase mesaconate levels in the gut to reduce inflammation in Crohn's Disease mouse models.
bioRxiv · Oct 7, 2026 · PreprintImmunology