Cellular uptake of folate-olaparib conjugates via folate receptor-mediated endocytosis: Potential for selective delivery of DNA damage response inhibitors into tumour cells
Vassilios Bavetsias, Lisa Pickard, Sara Díaz-Sánchez, Sharon Gowan, Francesca Wood, Ruth Ruddle, Chris Wong, Humera H. Sharif, Florence I. Raynaud, Rosemary Burke, Anderson Wang, Julian Blagg, Vladimir Kirkin, Olivia Rossanese, Udai Banerji
This paper develops folate-olaparib conjugates that selectively enter FR-overexpressing tumor cells via endocytosis and inhibit PARylation.
bioRxiv · Sep 24, 2026 · PreprintBiochemistry