Aging activates latent enhancers that can be reversed withexercise
Jack Clarke, Fujian Wu, Vaibhao Janbandhu, Samuel Bagot, David Zheng, Pablo Mantilla Puccetti, Delfine Cheng, Xueqian Zhuang, Hoor E Maksura, Xuan Zhang, Alvaro Gonzalez Rajal, Julie Feng, Yen Tran, Alexander R Pinto, Peter K Koo, , Emily S Wong
This study identifies age-acquired enhancers in mouse hearts and shows that exercise can reverse their activation.
bioRxiv · Nov 4, 2026 · PreprintMolecular Biology