ImmunologybioRxivPreprint
A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn's disease
Thomas Laurent, Monika Mykhaylyshyn, Jake Thomas…·J. P. D. Martin
The paper identifies a JAK-STAT-activated myeloid subset, IFIM, associated with anti-TNF resistance in Crohn's disease and proposes JAK inhibition as a therapeutic strategy.