Azucena Salas

The paper identifies a JAK-STAT-activated myeloid subset, IFIM, associated with anti-TNF resistance in Crohn's disease and proposes JAK inhibition as a therapeutic strategy.

The paper uses single-cell multiomics to identify shared and unique immune dysfunction features in Parkinson's disease and inflammatory bowel disease across gut, plasma, and stool samples.

This paper constructs a single-cell atlas of circulating immune cells to understand inflammation across diseases and develops a classifier for inflammatory diseases.

The paper identifies TL1A-driven cellular and transcriptomic changes in rectal mucosa of Crohn's disease patients with perianal fistulizing disease, revealing a novel TL1A-LT1{beta}2/IL-22 axis independent of TNF signaling.

The paper investigates resistance to JAK inhibitors in UC by analyzing single-cell RNA data from responders and non-responders, identifying hyperactivation of myeloid cells as a key mechanism.

The paper investigates the relationship between mitochondrial dysfunction and anti-TNF treatment response in ulcerative colitis using both murine and human samples, finding metabolic pathways and mitochondrial homeostasis are involved.

FixNCut is a reversible fixation and dissociation method that preserves RNA integrity and cellular composition in human and mouse tissues, enabling robust single-cell and spatial analyses.