Single-cell multi-omics maps clonal IEL expansion and epithelial remodelling in refractory coeliac disease
Michael Li, Arman Safavi, Jerome Samir, Raymond H. Y. Louie, Esmaeil Roohparvar Basmenj, Martina Bonomi, Thiruni N. Adikari, Brian Gloss, Jun Xing, Katherine Jackson, Andrew Calcino, Dan Suan, Valentina Vaira, Claire Milthorpe, Melinda Y. Hardy, , Fabio Luciani
This study identifies clonal IEL expansion and epithelial remodelling in RCD1 using single-cell multi-omics, showing distinct immune and epithelial states compared to ACD.
bioRxiv · Sep 3, 2026 · PreprintImmunology