Fabio Luciani

This study identifies clonal IEL expansion and epithelial remodelling in RCD1 using single-cell multi-omics, showing distinct immune and epithelial states compared to ACD.

MiniMarS identifies the minimal number of protein markers for cell type annotation across multiple datasets and improves rare population identification.

The paper traces the evolution of autoantibodies in HCV-CV patients, revealing convergent somatic mutations and compromised solubility in pathogenic B cells.

This study examines how viral fitness and immune responses interact in HCV infection, showing fitness decreases early but rebounds with mutations, and strong CD8+ T-cell responses drive chronic infection.

This study evaluates the analytical validity of nanopore sequencing for SARS-CoV-2 genome analysis, finding high accuracy for SNVs but limitations in detecting short indels and low-frequency variants.

VDJView is a tool for analysing immune single-cell multi-omics data, integrating gene expression, immune receptors, and clinical metadata to identify antigen-specific gene signatures and clonal expansions.

This paper introduces RAGE-seq, a method combining long-read and short-read sequencing to analyze lymphocyte clonal and transcriptional features in breast cancer tissues.

VDJPuzzle 2.0 reconstructs full-length B-cell receptor sequences from scRNA-seq with high accuracy, validated against Sanger sequencing.

This study examines how sequencing depth and read length affect scRNA-seq data quality, finding that sufficient depth and length improve TCRβ reconstruction and gene expression accuracy in T cells.