ROS-induced translational regulation--through spatiotemporal differences in codon recognition--is a key driver of brown adipogenesis
Jun Yu Ip, Indrik Wijaya, Li Ting Lee, Yuhua Lim, Deryn En-Jie Teoh, Cheryl Siew Choo Chan, Cui Liang, Thomas J. Begley, Peter C. Dedon, Huili Guo
The paper shows that ROS-induced translational bias during brown adipogenesis supports mitochondrial biogenesis by preferentially translating G/C-ending codons through tRNA modification.
bioRxiv · Dec 22, 2023 · PreprintMolecular Biology