Field–Flow–Front mapping of breast cancer evolutionary dynamics in situ
Yuhong Zhang, Juan Ji, Mingquan Gao, Yu Zhang, Zifei Wu, Chuan Wu, Junchao Wang, Hongyuan Jia, Yi Yang, Luo Liang, Shuang Li, Yajie Tu, Lan Lei, Yaxing Pei, Hong Yang, , Weidong Wang
This paper maps breast cancer evolution in situ using spatial transcriptomics and other data to show that tumor progression is driven by spatially coherent fronts rather than predefined clonal branches.
bioRxiv · Jun 23, 2026 · PreprintCancer Biology