Author

Chuan Wu

University of Electronic Science and Technology of ChinaPrimary ORCID profile (0000-0003-2288-353X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Chuan WuiD1 paper · National Institutes of Health

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Hong YangiD· 2 shared Hongyuan Jia· 2 shared Juan JiiD· 2 shared Junjie LiiD· 2 shared Lan Lei· 2 shared Luo Liang· 2 shared Mingquan Gao· 2 shared Rong LiiD· 2 shared

Activity by Year

2017-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Hong YangORCID

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Author profile →

4 papers

Recent·Most cited

Phenotype-cloud reorganization shapes cancer progression and therapeutic adaptation

Yuhong Zhang, Juan Ji, Mingquan Gao, Yiyao Zhang, Zifei Wu, Chuan Wu, J. Wang, Hongyuan Jia, Yiyan Yang, Luo Liang, Shuang Li, Yajie Tu, Lan Lei, Yaxing Pei, Hong Yang, , Weidong Wang

This study identifies phenotype-cloud transitions as an organizational feature of cancer progression and therapeutic adaptation, showing how tumours reorganize phenotypic states during progression and treatment.

bioRxiv · Oct 21, 2026 · PreprintCancer Biology

Field–Flow–Front mapping of breast cancer evolutionary dynamics in situ

Yuhong Zhang, Juan Ji, Mingquan Gao, Yu Zhang, Zifei Wu, Chuan Wu, Junchao Wang, Hongyuan Jia, Yi Yang, Luo Liang, Shuang Li, Yajie Tu, Lan Lei, Yaxing Pei, Hong Yang, , Weidong Wang

This paper maps breast cancer evolution in situ using spatial transcriptomics and other data to show that tumor progression is driven by spatially coherent fronts rather than predefined clonal branches.

bioRxiv · Jun 23, 2026 · PreprintCancer Biology

PD1-induced Shp2 condensation organizes inhibitory signalosomes through selective substrate partitioning

Takeya Masubuchi, George A. Wen, Xiaoxian Song, Keshav Gaddam, Haian Shao, Chuan Wu, Enfu Hui

This study shows that PD1-induced Shp2 phase separation forms dynamic condensates that organize inhibitory signaling by selectively partitioning substrates, thereby suppressing T cell activation.

bioRxiv · Mar 11, 2026 · PreprintBiochemistry

T helper cells modulate intestinal stem cell renewal and differentiation

Moshe Biton, Adam L. Haber, Semir Beyaz, Noga Rogel, Christopher Smillie, Karthik Shekhar, Alexandra Schnell, Zuojia Chen, Chuan Wu, Jose Ordovas-Montanes, David Alvarez, Rebecca H. Herbst, Itay Tirosh, Grace Burgin, Danielle Dionne, , Ramnik J. Xavier

This study shows that T helper cells interact with intestinal stem cells via MHCII to regulate their renewal and differentiation, with distinct effects based on Th subtype and cytokine signaling.

bioRxiv · Nov 14, 2017 · PreprintImmunology