Author

Junde Xu

Chinese University of Hong Kong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein design· 2 Assay:protein sequence· 2 Approach:transformer / foundation model· 1

Frequent Co-Authors

Guangyong CheniD· 2 shared Aimin PaniD· 1 shared Anni Li· 1 shared Bin Cui· 1 shared Fangyu WangiD· 1 shared Fei YangiD· 1 shared Hanqun CaoiD· 1 shared Jiabin Yin· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Guangyong ChenORCID

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2 papers

Recent·Most cited

CatESO: Differentiable Enzyme Sequence Optimization Guided by Substrate-Aware kcat Prediction

Zhenjia Gan, Yuzhi Xu, Junde Xu, Zhihao Wu, Juping Huang, Jiabin Yin, Guangyong Chen, John Z. H. Zhang

CatESO optimizes enzyme sequences to improve catalytic turnover by integrating kcat prediction with differentiable design, achieving higher predicted activity and structural confidence than existing methods.

Journal of the American Chemical Society · Sep 4, 2026Peer-reviewedBiochemistry

InstructPLM: Aligning Protein Language Models to Follow Protein Structure Instructions

Jiezhong Qiu, Junde Xu, Jie Hu, Hanqun Cao, Liya Hou, Zi-Jun Gao, Xinyi Zhou, Anni Li, Xiujuan Li, Bin Cui, Fei Yang, Shuang Peng, Ning Sun, Fangyu Wang, Aimin Pan, , Guangyong Chen

InstructPLM aligns a protein language model with structure instructions to generate diverse proteins, improving performance over existing models in sequence recovery and activity.

bioRxiv · Apr 17, 2024 · PreprintBioinformatics