Pharmacological activation of mitophagy prevents calcific aortic valve disease by targeting dysregulated mitochondrial-to-nuclear communication
Dao Zhou, Hanyi Dai, Junhao Qiu, Yihan Pan, Wangxing Hu, Hongyu Lu, Junhui Xue, Haochang Hu, Dilin Xu, Jingling Dai, Jin Lu, Shuangshuang Yang, Ningjing Qian, Yufei Li, Si Cheng, , Xianbao Liu
This study shows that activating mitophagy with TJ0113 prevents calcific aortic valve disease by restoring mitochondrial-to-nuclear communication disrupted in diseased valves.
bioRxiv · Nov 2, 2026 · PreprintPathology