Conformational Reorganization of a Processive Cellulase on Crystalline Cellulose
Sai Venkatesh Pingali, Junhong He, Loukas Petridis, Barbara R. Evans, William T. Heller, Emal M. Alekozai, Xiaolin Cheng, Benjamin Lindner, Jeremy Smith, Volker S. Urban, Brian H. Davison, Paul A. Langan, Hugh O’Neill
This study uses SANS and molecular dynamics to show that Cel7A adopts distinct conformations when bound to cellulose compared to free solution, highlighting dynamic structural changes during catalysis.
bioRxiv · Oct 23, 2026 · PreprintBiochemistry