A Tissue-Targeted Immunotherapy Protects Against Recurrent Ocular Herpes Infection and Disease, and Alleviates the Associated Cognitive, Behavioral, and Social Deficits in a 'Humanized' HLA Transgenic Mouse Model of UVB-Induced Reactivation
Sweta Karan, Swayam Prakash, Aziz Alami Chentoufi, Khan Intharachalit, Sarah Xue Le Ng, Junseong Hwang, Chhaya Maurya, Lbachir BenMohamed
This paper demonstrates that a PPK immunotherapy reduces HSV-1 reactivation and associated neurobehavioral deficits in a humanized mouse model.
bioRxiv · Oct 2, 2026 · PreprintImmunology