Time-dependent enhancement of mRNA vaccines by 4-1BB costimulation
Sarah Sanchez, Tanushree Dangi, Bakare Awakoaiye, Nahid Irani, Slim Fourati, Justin Richner, Pablo Penaloza‐MacMaster
This study shows that administering 4-1BB costimulatory antibodies after 96 hours post-mRNA vaccination enhances CD8 T cell responses and protection against breakthrough infections.
Journal of Clinical Investigation · Oct 21, 2024Peer-reviewedImmunology