K. Andries

Minimal effective dose of oral bedaquiline and activity of a long acting formulation of bedaquiline in the murine model of leprosy

This study determines the minimal effective dose of oral bedaquiline and evaluates the efficacy of a long-acting injectable formulation in a murine model of leprosy, finding that the MED is 3.3 mg/kg and the injectable form is less effective than oral administration.

Activity of a long-acting injectable bedaquiline formulation in a paucibacillary mouse model of latent tuberculosis infection

This study evaluates a long-acting injectable bedaquiline formulation in a mouse model of latent tuberculosis, showing its efficacy with fewer doses compared to daily oral regimens.