K. Atkins

Patient-derived response estimates from zero-passage organoids of luminal breast cancer

This study develops zero-passage organoids from luminal breast cancer patient samples to test genetic and pharmacologic perturbations, finding variable hormone responsiveness and complex interactions with sulforaphane and NQO1 knockout.

Pan-cancer Drivers are Recurrent Transcriptional Regulatory Heterogeneities in Early-stage Luminal Breast Cancer

The paper identifies recurrent transcriptional regulatory heterogeneities in early-stage luminal breast cancer using stochastic profiling and 10-cell RNA sequencing, revealing genes associated with EMT and pan-cancer drivers.