S. Singh

A large-scale crowd-sourced annotated acoustic dataset of Indian fauna

The paper creates a crowd-sourced acoustic dataset of Indian fauna to support biodiversity monitoring and deep learning applications in conservation.

Lower Airway Dysbiosis in NTM+ Bronchiectasis is Associated with NET-Predominant Severe Phenotypes

This study links lower airway microbiota and neutrophilic inflammation in NTM+ bronchiectasis to severe disease phenotypes through network analysis and preclinical models.

Adjusted vascular contractility relies on integrity of progranulin pathway: Insights into mitochondrial function

This study shows that progranulin (PGRN) is essential for vascular contractility by regulating mitochondrial function, mitophagy, and redox signaling in vascular smooth muscle cells.

CREB drives acinar cells to ductal reprogramming and promotes pancreatic cancer progression in preclinical models of alcoholic pancreatitis

This study shows CREB promotes acinar-to-ductal reprogramming and pancreatic cancer progression in alcoholic pancreatitis models by enhancing fibrosis and tumor growth.

Discordance in Genotypic and Phenotypic anti-tuberculosis drug susceptibility results: time to reconsider critical concentration.

The paper identifies phenotypic and genotypic discordance in rifampicin resistance of Mycobacterium tuberculosis isolates, showing 15% of isolates misclassified as susceptible despite low-level resistance mutations.

Autoimmunity and clinical pathology amelioration in SLE by Dexamethasone primed Mesenchymal Stem Cell derived conditioned media

This study evaluates dexamethasone-primed mesenchymal stem cell conditioned media for treating SLE, showing improved immunomodulation and organ protection compared to standard therapies.

TGFb-ANGPT2-Tie2 axis in cancer-associated fibroblasts reprograms oral cancer cells to embryonic-like cell state with predictive significance of poor prognosis

The paper identifies the TGFβ-ANGPT2-Tie2 axis in cancer-associated fibroblasts that reprograms oral cancer cells to an embryonic-like state, linked to poor prognosis.

Tetra hydroxy ethyl disulfate disodium: a novel non-resistant antibacterial chelating agent

This study identifies THES as a non-resistant antibacterial agent that disrupts bacterial cell membranes through chelation, showing efficacy against MDR bacteria without resistance development.

The reparative immunologic consequences of stem cell transplantation as a cellular therapy for refractory Crohn's disease

This study investigates how stem cell transplantation (SCT) restores immune function in refractory Crohn's disease by analyzing immune cell remodeling and HSC heterogeneity using single-cell RNA sequencing and functional assays.

Obg-like ATPase 1 Genetic Deletion Leads to Dilated Cardiomyopathy in Mice and Structural Changes in Drosophila Heart

This study shows that Ola1 deletion causes dilated cardiomyopathy in mice and structural heart defects in Drosophila.

SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics

This study identifies SNX10 as a negative regulator of piecemeal mitophagy and mitochondrial bioenergetics, showing its role in modulating mitochondrial homeostasis and cell survival.

A Decade in a Systematic Review: The Evolution and Impact of Cell Painting

This paper reviews methodological advancements in Cell Painting over a decade, highlighting improvements in protocols, feature extraction, and machine learning applications for biological insights.

Impact of Species-Specific Plant Growth-Promoting Rhizobacteria (PGPR) on Maize (Zea mays) Phenotypic and Biochemical Diversity

This study evaluates the impact of four PGPR species on maize growth and biochemical parameters, finding significant increases in chlorophyll, enzymes, and yield.

A dynamin-like protein in the human malaria parasite plays an essential role in mitochondrial homeostasis and fission during asexual blood stages

This study identifies PfDyn2, a dynamin-like protein in P. falciparum, essential for mitochondrial fission and homeostasis during asexual blood stages of malaria.

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes

This study identifies PLD3 and PLD4 as enzymes synthesizing S,S-BMP, a lysosomal phospholipid critical for lipid degradation and brain health.

Assessment of Antibiotic Resistance Profiles in Cultivable Coliform Organisms Isolated from Ganga River Waters Across the Upper, Middle, and Lower Ganga Stretch

The paper assesses antibiotic resistance in coliforms from Ganga River waters, finding varying resistance levels across different river stretches.

Genome-Wide Identification of G-Quadruplex forming regions in Arabidopsis: Unraveling the Role of Pif like Helicase (AtPLH1) in Gene Regulation and Stress Response

This study identifies G-quadruplex regions in Arabidopsis and shows AtPLH1 regulates gene expression related to stress response and transcription.

Evaluation Of Suitability Analysis of Gangetic Water from Upper, Middle, And Lower Ganga Rivers

This study evaluates water quality across the Ganga River's upper, middle, and lower stretches to determine suitability for drinking, irrigation, and industrial use, highlighting variations in parameters like E. coli, sodium levels, and heavy metals.

Theileria annulata Infection Promotes p53 suppression, Genomic Instability and DNA deaminase APOBEC3H upregulation leading to cancer-like phenotype in host cells

This study identifies somatic mutations and genomic instability in Theileria annulata-infected leukocytes, linking them to cancer-like phenotypes through ROS1, TP53 suppression, and APOBEC3H upregulation.

Expression of Plasmodium Major Facilitator Superfamily Protein in Transporters-Delta Candida Identifies a Drug Transporter

The paper assesses the functional relevance of a Plasmodium MFS protein as a drug transporter using Candida glabrata, showing antifungal resistance and antimalarial properties.

The ELF3-BBX24/BBX25-PIF4 module controls thermosensory growth in Arabidopsis

This study identifies the ELF3-BBX24/BBX25-PIF4 module as a regulatory network controlling thermosensory growth in Arabidopsis by modulating PIF4 activity through interactions with ELF3.

NEKL-4 regulates microtubule stability and mitochondrial health in C. elegans ciliated neurons

This study shows NEKL-4 regulates ciliary stability and mitochondrial health in C. elegans ciliated neurons through kinesin activation and mitochondrial homeostasis.

UBA1-CDK16: A Sex-Specific Chimeric RNA and Its Role in Immune Sexual Dimorphism

The paper identifies a female-specific chimeric RNA, UBA1-CDK16, and shows its role in myeloid differentiation and immune sexual dimorphism.

Characterization of a new lacrimal gland cell line in 2D and 3D cell culture models

This paper develops an immortalized human lacrimal gland epithelial cell line for studying dry eye disease mechanisms and potential treatments.

PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment.

This study shows Mtb induces PPARγ in hepatocytes to create lipid droplets and drug-tolerant environments, contributing to systemic pathogenicity and metabolic impairments during TB infection.

Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

This paper evaluates SpiD3, a novel spirocyclic dimer, showing potent anti-leukemic effects in CLL cells, including resistance to ibrutinib, by targeting NF-κB signaling and the UPR.

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.

Unveiling the Immune Dynamics of Neisseria Persistent Oral Colonization: A Roadmap for Innovative Vaccine Strategies

This study investigates immune dynamics during Neisseria musculi colonization in mice, identifying key genes and pathways for immune homeostasis and offering insights for vaccine development.

G6PD deficiency mediated impairment of iNOS and lysosomal acidification affecting phagocytotic clearance in microglia in response to SARS-CoV-2

This study shows that G6PD deficiency in microglia impairs iNOS-mediated NO production and lysosomal acidification, leading to reduced phagocytosis of SARS-CoV-2 and increased COVID-19 severity.