Protection from viral rebound after therapeutic vaccination with an adjuvanted DNA vaccine is associated with SIV-specific polyfunctional CD8 T cells in the blood and mesenteric lymph nodes
H. C. Tunggal, P. V. Munson, M. A. O'Connor, N. Hajari, S. E. Dross, D. Bratt, J. T. Fuller, K. Bagley, D. H. Fuller
This study shows that a therapeutic DNA vaccine with adjuvants protects some SIV-infected macaques from viral rebound by enhancing polyfunctional CD8 T cells in blood and gut lymph nodes.
bioRxiv · Sep 16, 2020 · PreprintMicrobiology