Combination of memantine and alpha7 nicotinic acetylcholine receptor ligands exerts superior efficacy over monotreatments to improve cognitive performance of aged rats
N. Bruszt, Z. K. Bali, L. V. Nagy, K. Bodo, P. Engelmann, I. Ledneczky, Z. Nemethy, B. Lendvai, I. Hernadi
This study shows that combining memantine with 7 nAChR agonists or PAMs improves cognitive performance in aged rats more than either drug alone.
bioRxiv · Sep 20, 2023 · PreprintPharmacology & Toxicology