Poly(ADP-ribose) potentiates ZAP antiviral activity
O. Pornillos, G. Xue, K. Braczyk, D. Goncalves-Carneiro, H. Ong, D. M. Dawidziak, K. Zawada, W. Yueping, K. K. Zadrozny, B. K. Ganser-Pornillos, P. D. Bieniasz
This study shows that poly(ADP-ribose) enhances ZAP's ability to degrade viral RNA by binding to ZAP's WWE domains, improving its antiviral activity against HIV-1.
bioRxiv · Dec 17, 2020Microbiology