O. Pornillos

This study determines the structural basis of HIV-1 maturation inhibitor binding and resistance using NMR, revealing an allosteric mechanism and conformational changes in SP1 variants.

This study identifies a molecular switch in HIV-1 capsid protein that controls capsid assembly and host factor binding, and is a target for the inhibitor lenacapavir.

This study uses molecular dynamics simulations and cryo-ET to show HIV-1 capsids exhibit strain patterns and rupture via crack propagation along high-strain regions.

This study shows that poly(ADP-ribose) enhances ZAP's ability to degrade viral RNA by binding to ZAP's WWE domains, improving its antiviral activity against HIV-1.

This study shows that destabilizing the HIV-1 capsid lattice leads to premature loss of the viral genome and integrase enzyme in infected cells.

This study identifies TRIM69 as an IFN-induced antiviral factor that inhibits VSVIND replication by targeting its phosphoprotein P through a novel transcriptional inhibition mechanism.