NOVEL NUCLEAR ROLE OF HDAC6 IN PROGNOSIS AND THERAPEUTIC TARGET FOR COLORECTAL CANCER
D. J. Garcia-Dominguez, L. Hontecillas-Prieto, M. Kaliszczak, M. He, M. Burguillos, R. El Bekay, V. B. Abdul-Salam, K. Combiz, K. Shah, k. O'Neill, E. de Alava, A. Silver, N. Syed, E. O. Aboagye, N. Hajji
This study identifies a novel nuclear role of HDAC6 in colorectal cancer prognosis and therapy, showing its association with chromatin relaxation, gene expression, and synergistic effects with DNA damaging agents.
bioRxiv · Nov 2, 2020 · PreprintCancer Biology