M. He

Perturbational single-cell profiling of patient tumors defines lineage- and context-specific programs of innate immune resistance

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

Muscone-specific olfactory protein reveals the putative scent-marking pheromone in the Sunda pangolin (Manis javanica)

This study identifies muscone as a potential male-specific scent-marking pheromone in Sunda pangolins through functional expression of odorant-binding proteins and behavioral assays.

Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy

This paper develops a dual-targeting compound that eliminates regulatory B cells and overcomes STING resistance in pancreatic cancer, improving immunotherapy outcomes.

Peptide-based capture-and-release purification of extracellular vesicles and statistical algorithm enabled quality assessment

This paper introduces a peptide-based EV isolation method and a statistical algorithm to assess EV quality, showing improved identification of tumor markers in pancreatic cancer samples.

The role of m6A methyltransferase WTAP in inflammatory response of atherosclerosis through NF-κB/NLRP3 mediated pyroptosis

This study shows that WTAP promotes LPS-induced pyroptosis and inflammation in endothelial cells by enhancing NF-κB p50 function and facilitating its interaction with NLRP3.

Cell type-specific translational regulation by human DUS enzymes

This study identifies DUS enzymes' role in tRNA modification and shows cell type-specific effects on translation.

Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse model of tubular aggregate myopathy

Voluntary wheel running improves muscle function and reduces tubular aggregates in a mouse model of tubular aggregate myopathy.

CRISPR-Cas9 Engineered Extracellular Vesicles for the Treatment of Dominant Progressive Hearing Loss

The paper develops a scalable microfluidic electroporation system to load gRNA:Cas9 RNP complexes into extracellular vesicles, achieving effective gene therapy for hearing loss in a mouse model.

Adaptive-learning physics-aware light-field microscopy enables day-long and millisecond-scale super-resolution imaging of 3D subcellular dynamics

This paper introduces Alpha-LFM, a physics-aware deep learning framework for 3D super-resolution imaging of living cells, achieving high resolution, speed, and low phototoxicity over long periods.

Mitochondrial Pyruvate Carrier Inhibition Attenuates Hepatic Stellate Cell Activation and Liver Injury in a Mouse Model of Metabolic Dysfunction-associated Steatotic Liver Disease

Effect of Total Sphingomyelin Synthase Activity on Low Density Lipoprotein Catabolism in Mice

This study shows that total sphingomyelin synthase (SMS) deficiency reduces LDL receptors and impairs LDL catabolism in mice, while SMS2 deficiency does not have this effect.

Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in mice.

The paper shows that lower adipose lipin 1 in humans correlates with metabolic issues, and mice lacking adipocyte lipin 1 develop metabolic disorders.

MYSM1 co-activates ERα action via histone and non-histone deubiquitination to confer antiestrogen resistance in breast cancer

This study identifies MYSM1 as an ER co-activator that promotes antiestrogen resistance in breast cancer through histone and non-histone deubiquitination.

Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

This study links age-related prefrontal glutamate levels to working memory deficits and decision-making impairments in older adults.

Distinct Single-cell Immune Ecosystems Distinguish True and De Novo HBV-related Hepatocellular Carcinoma Recurrences

This study identifies distinct immune ecosystems in true and de novo HBV-related HCC recurrences using single-cell and bulk RNA-sequencing, revealing differences in T cell phenotypes and immune interactions that may inform immunotherapy strategies.

Hinokitiol alters Gene Expression in Aspergillus fumigatus, protects against fungal keratitis by Reducing Fungal Load, LOX-1, Proinflammatory cytokines and Neutrophil Infiltration

This paper shows that Hinokitiol reduces fungal load and inflammation in Aspergillus fumigatus keratitis by altering gene expression and inhibiting fungal growth.

FOXO dictates initiation of B cell development and myeloid restriction in common lymphoid progenitors

The paper shows that FOXO1 and FOXO3 are essential for B cell development and myeloid restriction in common lymphoid progenitors, with their combined loss causing developmental block and loss of B cell lineage.

Flv3A facilitates O2 photoreduction and affects H2 photoproduction independently of Flv1A in diazotrophic Anabaena filaments

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

Nano Pom-poms Prepared Highly Specific Extracellular Vesicles Expand the Detectable Cancer Biomarkers

The paper introduces NanoPoms for specific EV isolation, enabling expanded cancer biomarker detection through multi-omic analysis of bladder cancer patient fluids.

High-speed large-scale 4D activities mapping of moving C. elegans by deep-learning-enabled light-field microscopy on a chip

This paper develops a chip-based system combining microfluidics and light-field microscopy with deep learning to high-speed 4D image and analyze moving C. elegans.

DNA demethylation switches the drivers of Foxp3 expression to maintain regulatory T cell identity

The paper shows DNA demethylation of Foxp3 enhancer CNS2 switches transcriptional drivers to maintain Treg identity by stabilizing Foxp3 expression.

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.

NOVEL NUCLEAR ROLE OF HDAC6 IN PROGNOSIS AND THERAPEUTIC TARGET FOR COLORECTAL CANCER

This study identifies a novel nuclear role of HDAC6 in colorectal cancer prognosis and therapy, showing its association with chromatin relaxation, gene expression, and synergistic effects with DNA damaging agents.

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

The paper identifies FOXA1 reprogramming in NEPC and shows its role in maintaining NE lineage features through epigenomic profiling.

Bio-Orthogonal Chemistry Enables Solid Phase Synthesis of Long RNA Oligonucleotides

This paper develops a bio-orthogonal chemistry method for synthesizing long RNA oligonucleotides, achieving 76-nt tRNA and 101-nt sgRNA with high purity and functional fidelity.

Identification of Lysine Isobutyrylation as A New Histone Modification Mark

The paper identifies lysine isobutyrylation as a new histone modification mark and shows its role in epigenetic regulation and cellular physiology.

Protein enhanced NIR-IIb emission of indocyanine green for functional bioimaging

This study demonstrates that indocyanine green (ICG) emits strong NIR-IIb fluorescence when dissolved in protein solutions, enabling high-resolution bioimaging with improved signal-to-background ratio.

Biologically excretable AIE dots for visualizing through the marmosets intravitally: horizons in future clinical nanomedicine

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

Effects of High-Grain Diet with Buffering Agent on the Milk Protein Synthesis in Lactating Goats

This study examines how a high-grain diet with a buffering agent affects amino acid levels in the blood and milk protein synthesis in lactating goats, finding increased amino acid concentrations and mTOR pathway activation.