Author

K. E. Hurst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:metabolomics· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

B. P. Riesenberg· 3 shared E. G. Hunt· 3 shared J. E. Thaxton· 3 shared P. Gao· 3 shared A. M. Andrews· 2 shared A. S. Kennedy· 2 shared E. J. Gandy· 2 shared C. M. Paulos· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

B. P. Riesenberg

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Acetyl-CoA Carboxylase Obstructs CD8+ T-Cell Lipid Utilization and Energy Synthesis in the Tumor Microenvironment

E. G. Hunt, K. E. Hurst, B. P. Riesenberg, A. S. Kennedy, E. J. Gandy, A. M. Andrews, E. D. Wallace, P. Gao, M. Coleman, J. E. Thaxton

This study shows that acetyl-CoA carboxylase (ACC) activity in T cells within the tumor microenvironment inhibits lipid utilization and energy synthesis, and its restriction enhances T cell survival and antitumor function.

bioRxiv · Nov 16, 2023 · PreprintImmunology

Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control

B. P. Riesenberg, E. J. Gandy, A. S. Kennedy, E. G. Hunt, K. E. Hurst, E. L. Sedlacek, P. Gao, M. J. Emanuele, J. Modliszewski, J. M. Green, J. J. Milner, L. Wiseman, J. E. Thaxton

This study shows that enhancing the adaptive IRE1 UPR pathway in T cells improves tumor control by reducing mitochondrial toxicity and chronic ER stress.

bioRxiv · Nov 16, 2023 · PreprintImmunology

Stress-Mediated Attenuation of Translation Undermines T Cell Tumor Control

B. P. Riesenberg, E. G. Hunt, M. D. Tennant, K. E. Hurst, A. M. Andrews, L. R. Leddy, D. M. Neskey, E. G. Hill, G. O. R. Rivera, C. M. Paulos, P. Gao, J. E. Thaxton

This study shows that solid tumor microenvironment stress reduces T cell protein translation via the UPR and p-eIF2, and that proteasome stimulation can reverse this effect to enhance antitumor immunity.

bioRxiv · Jan 31, 2022 · PreprintImmunology