Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains
A. Jurisic, C. Robin, P. Tarlykov, L. Siggens, B. Schoell, A. Jauch, K. Ekwall, C. S. Sorensen, M. Lipinski, M. Shoaib, V. Ogryzko
The paper introduces Topokaryotyping, a microscopy-based method to analyze single-cell genomic positioning relative to nuclear landmarks, showing variability and stress-dependent changes in emerin-associated domains.
bioRxiv · Aug 27, 2018Cell Biology