A. Jauch

STIL overexpression shortens lifespan and reduces tumor formation in mice

This study shows that STIL overexpression increases centrosome numbers, leading to aneuploidy and reduced tumor formation and lifespan in mice.

Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH

The paper identifies a network of residues responsible for TWIK1 channel's pH-dependent shift in ionic selectivity from K+ to Na+ using MD simulations, mutagenesis, and electrophysiology.

A signalling rheostat controls chromosome segregation fidelity during early lineage specification and neurogenesis by modulating DNA replication stress

The paper identifies a signalling rheostat involving WNT, BMP, and FGF that modulates DNA replication stress and chromosome segregation fidelity during lineage specification and neurogenesis.

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

CloneTracer identifies differentiation routes in AML by adding clonal resolution to single-cell RNA-seq data, revealing disease-defining compartments and therapy response mechanisms.

Single cell multi-omics analysis of chromothriptic medulloblastoma highlights genomic and transcriptomic consequences of genome instability

This study analyzes single-cell multi-omics data from medulloblastoma to explore genomic and transcriptomic impacts of chromothripsis and its subclonal variation.

Maturation of the human B-cell receptor repertoire with age

This study examines age-related changes in human B-cell receptor repertoires, finding significant shifts in immunoglobulin gene usage and self-reactive antibody frequencies during early life and aging.

Induced aneuploidy disrupts MCF10A acini formation and CCND1 expression

This study shows that induced aneuploidy disrupts MCF10A acini formation and upregulates CCND1 expression through altered promoter-enhancer interactions.

Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains

The paper introduces Topokaryotyping, a microscopy-based method to analyze single-cell genomic positioning relative to nuclear landmarks, showing variability and stress-dependent changes in emerin-associated domains.

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

The paper identifies chromothripsis and chromoanasynthesis in tumors with DNA repair deficiencies and links them to MYC/MYCN amplification and therapeutic opportunities.