A Speedy Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors
W. R. Liu, K. S. Yang, X. R. Ma, Y. Ma, Y. R. Alugubelli, D. A. Scott, E. C. Vatansever, A. K. Drelich, Z. Z. Geng, L. R. Blankenship, B. Sankaran, H. E. Ward, Y. J. Sheng, J. C. Hsu, K. K. Kratch, , H. S. Hayatshahi
This study designs and synthesizes potent SARS-CoV-2 main protease inhibitors, with some showing IC50 values below 100 nM and high virus inhibition potency in cell assays.
bioRxiv · Jul 28, 2020 · PreprintBiochemistry