J. C. Hsu

This paper develops a scalable microfluidic method to produce silver sulfide nanoparticles for clinical imaging, showing high-quality output and efficient in vivo clearance.

This paper develops AgPCPP, biodegradable nanoparticles that enhance NIR imaging and photothermal therapy for breast cancer, showing safety and efficacy in vivo.

This study develops a theranostic gold nanoparticle for detecting and treating biofilm infections using photothermal ablation and photoacoustic imaging, showing superior efficacy against oral and wound infections compared to chlorhexidine.

The paper introduces a virus-free multiplex CAR-T cell therapy system called qCART, integrating four platforms to improve CAR-T development and manufacturing.

This paper demonstrates the efficient manufacturing of CD20/CD19 dual-targeted, iCasp9-regulatable CAR-TSCM cells using the virus-free qCART system, showing robust tumor eradication and safety.

This paper develops a virus-free gene therapy vector system, Quantum pBac, which improves transposition efficiency and payload capacity for CAR-T cell production.

The paper detects long SARS-CoV-2 nucleocapsid sequences in blood monocytes of patients within 2-6 days of hospital admission, suggesting early viral dissemination by myeloid cells.

This paper shows that K777, a cysteine protease inhibitor, blocks SARS-CoV-2 infection by inhibiting host cathepsin L, which is required for spike protein processing, with nanomolar efficacy in several cell lines.

This study designs and synthesizes potent SARS-CoV-2 main protease inhibitors, with some showing IC50 values below 100 nM and high virus inhibition potency in cell assays.