Conformational stability and order of Hoogsteen base pair induced by protein binding
K. KOLE, A. MALLICK GUPTA, J. Chakrabarti
The paper uses molecular dynamics simulations to show that protein binding stabilizes and orders Hoogsteen base pairs in DNA, with key roles for sugar-phosphate, sugar-base, and sugar-pucker torsion angles.
bioRxiv · May 8, 2023Biophysics