Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
K. R. Karan, C. Trumpff, M. Cross, K. M. Englestad, A. L. Marsland, P. McGuire, M. Hirano, M. Picard
This study examines cytokine responses and glucocorticoid sensitivity in leukocytes from patients with mitochondrial DNA defects, finding reduced IL-6 and IL-1β responses to LPS in those with mtDNA deletions.
bioRxiv · Dec 13, 2021Immunology