M. Cross

Metabolic immaturity of newborns and breast milk bile acids are the central determinants of heightened neonatal vulnerability to norovirus diarrhea

This study identifies metabolic immaturity in newborns and maternal bile acids in breast milk as key factors increasing vulnerability to norovirus diarrhea.

A gene selection analysis of TAS1R1 and TAS1R3 to examine human carnivory

This paper analyzes gene selection in TAS1R1 and TAS1R3 across ape clades to assess differences in meat taste perception between humans and other primates.

Mesothelial cells exhibit characteristics of perivascular cells in an in vitro angiogenesis assay

This study shows mesothelial cells can adopt a perivascular phenotype and support angiogenesis in vitro by aligning with endothelial networks and upregulating pericyte markers.

Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth

This study identifies a LKB1-LIF signaling axis in tumors that promotes immune evasion by reprogramming myeloid cells, and shows that inhibiting LIF signaling reduces tumor growth.

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

This study shows that DRP-104, a glutamine antagonist, suppresses KEAP1 mutant lung tumor growth and enhances response to checkpoint blockade by inhibiting glutamine metabolism and improving T cell function.

Leukocyte cytokine responses in adult patients with mitochondrial DNA defects

This study examines cytokine responses and glucocorticoid sensitivity in leukocytes from patients with mitochondrial DNA defects, finding reduced IL-6 and IL-1β responses to LPS in those with mtDNA deletions.

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.