Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine Approach
L. Sonnenkalb, J. Carter, A. Spitaleri, Z. Iqbal, M. Hunt, K. Malone, C. Utpatel, D. M. Cirillo, C. Rodrigues, K. S. Nilgiriwala, the CRyPTIC Consortium, P. W. Fowler, M. Merker, S. Niemann
This study identifies 230 genomic variants associated with resistance to bedaquiline and clofazimine in tuberculosis using experimental evolution, genome sequencing, and structural modeling.
bioRxiv · Mar 19, 2021Microbiology