Bromodomain 4 inhibition leads to MYCN downregulation in Wilms' tumor cells
A. D. Woods, C. Keller, N. E. Berlow, J. E. Michalek, B. Royer-Pokora, R. Purohit, K. E. Tranbarger Freier, M. Lathara, K. Matlock, G. Srivivasa, R. Veselska
This study shows that BRD4 inhibition reduces MYCN levels and suppresses proliferation in Wilms tumor cells, suggesting AZD5153 as a potential therapeutic agent.
bioRxiv · Jan 4, 2021 · PreprintCancer Biology