Modulation of the cAMP levels with a conserved actinobacteria phosphodiesterase enzyme reduces antimicrobial tolerance in mycobacteria
M. Thomson, K. Nunta, A. Cheyne, Y. Liu, A. Garza-Garcia, G. Larrouy-Maumus
This study identifies a phosphodiesterase enzyme that reduces cAMP levels in mycobacteria, increasing antimicrobial susceptibility and revealing a new target for antimicrobial development.
bioRxiv · Aug 26, 2020 · PreprintMicrobiology