Y. Liu

Construction of a breast cancer predictive nomogram based on diverse cell death methods and reveal tumor microenvironment characterization

The paper develops a breast cancer prognostic model and nomogram using LASSO Cox analysis and evaluates tumor microenvironment and drug sensitivity differences between subgroups.

Behavior- and Cell Type-Specific Cortico-Striatal Activity Decoupling in a Parkinson's Disease-Like Mouse Model

The paper shows that cortico-striatal activity decoupling occurs early in a Parkinson's Disease-like mouse model and is cell-type and behavior-specific.

Artificial light at night alters morphology, phenology, and reproductive capacity in an annual herb

This study shows that artificial light at night changes plant morphology, reproductive timing, and capacity in Elsholtzia densa, with mixed effects on fitness.

An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide

This study shows that AOAH inactivates intestinal LPS, reducing MASLD by preventing hepatic lipid accumulation and altering lipid metabolism gene expression.

Developmental priming of cancer susceptibility

The paper shows that early life epigenetic variation can prime cancer-susceptibility states that persist into adulthood and correlate with poor prognosis in human cancers.

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

2,2-Di-Fluoro-Derivatives of Fucose Can Inhibit Cell Surface Fucosylation Without Causing Slow Transfer to Acceptors

This paper evaluates 2,2-di-fluoro-fucose derivatives as FUT inhibitors, finding they inhibit fucosylation without slow transfer to acceptors, and show feedback inhibition of GDP-Fuc biosynthesis.

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

YAP/TAZ enhance P-body formation to promote tumorigenesis

This study shows YAP/TAZ promote P-body formation in cancer cells, enhancing tumorigenesis, and suggests targeting P-bodies or PNRC1 could be therapeutic.

Structural Basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex

This study presents cryo-EM structures of the Cas5-HNH/Cascade complex, revealing its DNA cleavage mechanism and the role of zinc-finger and divalent ions in enzyme activity.

An Omni-Mesoscope for multiscale high-throughput quantitative phase imaging of cellular dynamics and high-content molecular characterization

The paper introduces the Omni-Mesoscope, a cost-effective imaging platform that combines quantitative phase microscopy and multiplex fluorescence imaging to study cellular dynamics and molecular characteristics.

Stabilized D2R G-protein coupled receptor oligomers identify multi-state β-arrestin complexes

This study identifies D2R receptor mutants that stabilize oligomers and show biased recruitment of β-arrestin-2, leading to altered signaling outcomes.

SlNAP2 promoted fruit ripening by directly binding the ACS2 promoter and interacting with EIL3

This study identifies SlNAP2 as a NAC transcription factor that promotes tomato fruit ripening by directly binding the ACS2 promoter and interacting with EIL3 to enhance ethylene signaling.

Design of intrinsically disordered region binding proteins

The paper designs proteins that bind intrinsically disordered regions with high affinity and specificity across diverse targets.

Drug resistant pancreatic cancer cells exhibit altered biophysical interactions with stromal fibroblasts in imaging studies of 3D co-culture models

This study investigates how drug-resistant pancreatic cancer cells alter biophysical interactions with stromal fibroblasts in 3D co-culture models using imaging and RNA-seq analysis.

Ventral Morphology and Ecological Implications of Cindarella eucalla (Artiopoda, Xandarellida) from Chengjiang Biota, China

This study reconstructs the morphology of Cindarella eucalla using X-ray computed tomography and fluorescent microscopy, revealing features that suggest it lived in muddy, light-filled environments and had escape capabilities.

Moderate Cold Stress Enhance Drought Resistance through CCA1 via -an ABA- independent Pathway

This study shows that moderate cold stress improves Arabidopsis drought tolerance through the CCA1 pathway, independent of ABA, by promoting stomatal closure and proline accumulation before drought occurs.

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

Neuronal GPCR NMUR-1 regulates energy homeostasis in response to pathogen infection

This study shows that NMUR-1 in C. elegans neurons controls energy homeostasis and innate immune specificity through ATP regulation in response to bacterial pathogens.

RBM10 loss induces aberrant splicing of cytoskeletal and extracellular matrix mRNAs and promotes metastatic fitness.

This study shows that RBM10 loss causes aberrant splicing of cytoskeletal and ECM genes, leading to RAC1 activation and metastatic fitness in thyroid cancer.

Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis

This study identifies physical interactions between septins and the exocyst complex in fission yeast, showing septins guide exocyst localization for proper cytokinesis.

Uncovering the hidden RNA virus diversity in Lake Nam Co: evolutionary insights from an extreme high-altitude environment

This study identifies 742 RNA virus species in Lake Nam Co, revealing novel viral groups and evolutionary adaptations in an extreme high-altitude environment.

AI-driven high-throughput droplet screening of cell-free gene expression

This paper introduces DropAI, an AI-driven droplet-based screening method to optimize cell-free gene expression systems, achieving cost reduction and yield improvement.

Basal Cambrian soft-bodied segmented bilaterians preserved as microbial pseudomorphs

This study identifies microbial pseudomorphs as the earliest three-dimensional body fossils of segmented bilaterians from the basal Cambrian, revealing a diversified bilaterian world.

Bird brains fit the bill: morphological diversification and the evolution of avian brain size

This study shows that morphological traits, not socio-cognitive demands, are key predictors of brain size evolution in birds.

Collagen modification remodels the sarcoma tumor microenvironment and promotes resistance to immune checkpoint inhibition

This study shows that Plod2 promotes immune evasion in UPS sarcomas and that its inhibition enhances anti-Pd1 therapy efficacy.

Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease

This study shows acarbose improves metabolic health and reduces cognitive deficits in Western diet-fed 3xTg mice, suggesting it may help prevent or delay Alzheimer's disease.

Structure-Mechanics Principles and Mechanobiology of Fibrocartilage Pericellular Matrix: A Pivotal Role of Type V Collagen

This study investigates the structure-mechanical properties and mechanobiological functions of the pericellular matrix in fibrocartilage, highlighting the critical role of collagen V in maintaining its integrity and function.

The Hippo pathway effector YAP inhibits NF-kB signaling and ccRCC growth by opposing ZHX2

This study shows YAP inhibits NF-κB signaling and ccRCC growth by blocking ZHX2, a co-factor of NF-κB, and competes with ZHX2 for binding to p65.