Polarized Desmosome and Hemidesmosome Shedding via Exosomes is an Early Indicator of Outer Blood-Retina Barrier Dysfunction
B. Hernandez, N. P. Skiba, K. Ploessl, M. Strain, D. Grigsby, U. Kelly, M. A. Cady, V. Manocha, A. Maminishkis, T. Watkins, S. S. Miller, A. Ashley-Koch, W. D. Stamer, B. H. Weber, C. B. Rickman, M. Klingeborn
The paper shows that oxidative stress in RPE cells leads to exosome-mediated shedding of desmosomes and hemidesmosomes, indicating early blood-retinal barrier dysfunction.
bioRxiv · Jun 12, 2023Cell Biology