Local delivery of cell surface-targeted immunocytokines programs systemic anti-tumor immunity
L. Santollani, Y. J. Zhang, L. Maiorino, J. R. Palmeri, J. A. Stinson, L. R. Duhamel, K. Qureshi, J. R. Suggs, O. T. Porth, W. Pinney, R. Al Msari, K. D. Wittrup, D. J. Irvine
This study develops CD45-targeted immunocytokines that localize to immune cells in tumors and lymph nodes, eradicating both treated and distant tumors in mouse models.
bioRxiv · Jan 3, 2024 · PreprintImmunology