Targeting PI3K-gamma in myeloid driven tumour immune suppression: A Systematic Review and Meta-Analysis of the Preclinical Literature
H. Xu, S. N. Russell, K. Steiner, E. O'Neill, K. I. Jones
This paper reviews preclinical studies on PI3K-gamma inhibition to reverse myeloid-driven immune suppression in solid tumours, finding that combination therapies show greater antitumor effects than monotherapy.
bioRxiv · May 12, 2024Cancer Biology